実績紹介Research Achievements

2023

1.Chamoto K*, Yaguchi T*, Tajima M* (*equally contributed), Honjo T. Insights from 30-year journey: function, regulation and therapeutic modulation of PD1. Nat Rev Immnol, in press.

2.Kawakami H, Sunakawa Y, Inoue E, Matoba R, Noda K, Sato T, Suminaka C, Yamaki M, Sakamoto Y, Kawabata R, Ishiguro A, Akamaru Y, Kito Y, Yabusaki H, Matsuyama J, Takahashi M, Makiyama A, Hayashi H, Chamoto K, Honjo T, Nakagawa K, Ichikawa W, Fujii M. Soluble programmed cell death ligand 1 predicts prognosis for gastric cancer patients treated with nivolumab: Blood-based biomarker analysis for the DELIVER trial. Eur J Cancer 184: 10-20, 2023.

3.Zou Y, Yaguchi T. Programmed cell death-1 blockade therapy in melanoma: Resistance mechanisms and combination strategies. Exp Dermatol 32: 264-275, 2023.

4.Katada C, Yokoyama T, Hirasawa D, Iizuka T, Kikuchi D, Yano T, Honbu T, Yoshio T, Yoshimizu S, Ono H, Yabuuchi Y, Terai S, Hashimoto S, Takahashi K, Tanaka S, Urabe Y, Arima M, Tanabe S, Wada T, Furue Y, Oyama T, Takahashi A, Sakamoto Y, Muto M. Curative management after endoscopic resection for esophageal squamous cell carcinoma invading muscularis mucosa or shallow submucosal layer – multicenter real-world survey in Japan. Am J Gastoenterol 118: 1175-1183, 2023.

5.Katada C, Yokoyama T, Mure K, Doyama H, Nakanishi H, Shimizu Y, Yamamoto K, Furue Y, Tamaoki M, Koike T, Kawahara Y, Kiyokawa H, Konno M, Yokoyama A, Ohashi S, Ishikawa H, Yokoyama A, Muto M. Risk factors for the development of second primary esophageal squamous-cell carcinoma after endoscopic resection for esophageal squamous-cell carcinoma according to genetic polymorphisms related to alcohol and nicotine metabolism. Jpn J Clin Oncol, in press.

6.Katada C, Yokoyama T, Yano T, Suzuki H, Furue Y, Yamamoto K, Doyama H, Koike T, Tamaoki M, Kawata N, Hirao M, Kawahara Y, Ogata T, Katagiri A, Yamanouchi T, Kiyokawa H, Kawakubo H, Konno M, Yokoyama A, Ohashi S, Kondo Y, Kishimoto Y, Kano K, Mure K, Hayashi R, Ishikawa H, Yokoyama A, Muto M. Alcohol Consumption, Multiple Lugol-voiding Lesions, and Field Cancerization. DEN Open 4, e261, 2023.

7.Hirao M, Katada C, Yokoyama T, Yano T, Suzuki H, Furue Y, Yamamoto K, Doyama H, Koike T, Tamaoki M, Kawata N, Kawahara Y, Katagiri A, Ogata T, Yamanouchi T, Kiyokawa H, Kawakubo H, Konno K, Ishikawa H, Yokoyama A, Muto M. Metachronous primary gastric cancer after endoscopic resection in patients with esophageal squamous cell carcinoma. Gastic Cancer, in press.

8.Inoue T, Katada C, Shimizu T, Nikaido M, Higuchi H, Kishimoto Y, Muto M. Endoscopic resection combination with gel immersion and curved laryngoscope for superficial hypopharyngeal cancer. Endoscopy 55: E831-832, 2023.

9.Ishido K, Tanabe S, Katada C, Ishibashi Y, Kitahara G, Onoue M, Kubota Y, Furue Y, Wada T, Watanabe A, Kusano C. Evaluation of Prognostic Factors for Unresectable or Recurrent Gastric Cancer Treated with Nivolumab. J Gastrointest Cancer, in press.

10.Nomura M, Hosokai T, Tamaoki M, Yokoyama A, Matsumoto S, Muto M. Timing of the infusion of nivolumab for patients with recurrent or metastatic squamous cell carcinoma of the esophagus influences its efficacy. Esophagus, in press.

11.Uneno Y, Nomura M, Hosokai T, Kurakake Y, Fuki M, Shiomi H, Tamaoki M, Yokoyama A, Katada C, Muto M. Successful management of malignant pericarditis using nivolumab for metastatic esophageal squamous cell carcinoma: a case report. Internal Medicine, in press.

12.Kondo T, Kanai M, Matsubara J, Yamaguchi D, Ura T, Kou T, Itani T, Nomura M, Funakoshi T, Yokoyama A, Doi K, Tamaoki M, Yoshimura M, Uza N, Yamada T, Masui T, Minamiguchi S, Matsumoto S, Ishikawa H, Muto M. Association between homologous recombination gene variants and efficacy of oxaliplatin-based chemotherapy in advanced pancreatic cancer: prospective multicenter observational study. Med Oncol 40: 144, 2023.

2022

1.Tanaka K*, Chamoto K*(*equally corresponding), Saeki S, Hatae R, Ikematsu Y, Sakai K, Ando N, Sonomura K, Kojima S, Taketsuna M, Kim YH, Yoshida H, Ozasa H, Sakamori Y, Hirano T, Matsuda F, Hirai T, Nishio K, Sakagami T, Fukushima M, Nakanishi Y, Honjo T, Okamoto I. Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer. Sci Transl Med 14 (675): eabq0021, 2022.

2.Matsushima S, Ajiro M, Iida K, Chamoto K, Honjo T, Hagiwara M. Chemical induction of splice-neoantigens attenuates tumor growth. Sci Transl Med 14 (673): eabq6056, 2022.

3.Al-Habsi M*, Chamoto K*, Matsumoto K*, Nomura N*(*equally contributed), Zhang B, Sugiura Y, Sonomura K, Maharani A, Nakajima Y, Wu Y, Nomura Y, Menzies R, Tajima M, Kitaoka K, Haku Y, Delghandi S, Yurimoto K, Matsuda F, Iwata S, Ogura T, Fagarasan S, Honjo T. Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice. Science 28; 378 (6618): eabj3510, 2022.

4.Katoh Y, Yaguchi T* (*equally corresponding), Kubo A, Iwata T, Morii K, Kato D, Ohta S, Satomi R, Yamamoto Y, Oyamada Y, Ouchi K, Takahashi S, Ishioka C, Matoba R, Suematsu M, Kawakami Y*. Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody. J Immunother Cancer 10: e004616, 2022.

5.Muto M, Katada C, Yokoyama T, Yano T, Oda I, Ezoe Y, Tanabe S, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Ogata T, Katagiri A, Yamanouchi T, Matsuo Y, Kawakubo H, Omori T, Kobayashi N, Shimoda T, Ochiai A, Ishikawa H, Baba K, Amanuna Y, Yokoyama A, Ohashi S, Yokoyama A. Field effect of alcohol, cigarette smoking and their cessation on the development of multiple dysplastic lesions and squamous cell carcinoma: Long term multicenter cohort study. Gastro Hep Advances 1: 265-276, 2022.

6.Ishihara R, Katada C. History of endoscopic diagnosis and treatment for esophageal and pharyngeal squamous cell carcinoma. Dig Endosc Suppl 2: 23-26, 2022.

7.Saito Y, Kodashima S, Matsuda T, Matsuda K, Fujishiro M, Tanaka K, Kobayashi K, Katada C, Horimatsu T, Muto M, Ohtsuka K, Oda I, Kato M, Kida M, Hoteya S, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Kato M, Haruma K, Fujimoto K, Iishi H, Ogata H, Uemura N, Kaminishi M, Tajiri H, Inoue H. Current status of diagnostic and therapeutic colonoscopy in Japan: The Japan Endoscopic Database Project. Digestive Endoscopy 34: 144-152, 2022.

8.Yamamoto Y, Yoshida N, Yano T, Horimatsu T, Uedo N, Kawata N, Kanzaki H, Hori S, Yao K, Abe S, Katada C, Yokoi C, Ohata K, Doyama H, Yoshimura K, Ishikawa H, Muto M. Assessment of Outcomes From 1-Year Surveillance After Detection of Early Gastric Cancer Among Patients at High Risk in Japan. JAMA Netw Open 5: e2227667, 2022.

9.Oikawa J, Fukaya H, Wada T, Kishihara J, Sato T, Matsuura G, Nakamura H, Ishizue N, Katada C, Tanabe S, Niwano S, Kusano C, Ako J. Esophagogastric complications in radiofrequency and cryoballoon catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 33: 1160-1166, 2022.

10.Yoshio T, Minashi K, Mizusawa J, Morita Y, Tajika M, Fujiwara J, Yamamoto Y, Katada C, Hori S, Yano T, Takizawa K, Fukuda H, Muto M. Effect of chemoradiation on the development of second primary cancers after endoscopic resection of T1 esophageal squamous cell carcinoma. Esophagus 19: 469-476, 2022.